Blocking of the beta-latrotoxin channels in bimolecular lipid membranes by antibodies.

نویسندگان

  • O V Kolomytkin
  • S K Kasymov
  • S I Salikhov
چکیده

Asymmetric ion channels are formed in a bimolecular lipid membrane by beta-latrotoxin (LT) introduced to one (cis) side of the membrane. LT-specific antibodies added to the opposite (trans) side of the membrane block the current through the LT channels when a negative potential is applied to the cis side, no blockade is observed at positive potentials. LT-specific antibodies do not block the channel current when added to the cis compartment after removal of LT. LT-unspecific immunoglobulins have no influence on LT channel conductance.

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عنوان ژورنال:
  • General physiology and biophysics

دوره 7 2  شماره 

صفحات  -

تاریخ انتشار 1988